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NHR Screening & Profiling Services
DiscoveRx has two approaches for monitoring the activity of Nuclear Hormone Receptors. The Nuclear Translocation assays monitor movement of a cytoplasmic NHR to the nuclear compartment. In the second approach, the Protein Interaction Assays detect NHR interaction with a co-activator fusion protein. This direct, non imaging approach provides feasibility of antagonist screening, fewer off-target effects, and the ability to select novel chemotypes based on disruption of protein-protein interactions.
Nuclear Hormone Receptor Panel
The NHR panel consists of 25 PathHunter Nuclear Translocation or NHRPRO Protein Interaction Assays for screening and profiling, with 5 targets available in both assay formats.
Nuclear Translocation Assays
Protein Interaction Assays
*Also available in a scheduled panel
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