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Over 300 different ways to expedite your GPCR research!

Welcome to the final edition of the DiscoveRx Assay newsletter for 2009! This edition is packed with information on the latest product releases, new applications and special promotions to support all of your GPCR screening and profiling needs. We've listened to our readers this year and created a new, easy-to-navigate on-line newsletter! We welcome your suggestions on future topics that interest you. Send in your email to marketing@discoverx.com with your ideas.

What's New?

Novel Applications

Therapeutic Focus

Promotions!

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Announcing launch of HitHunter™ cAMP one-STEP

•Suspension-friendly, one step assay : Ideal for automation
•Simple, single addition chemiluminescent protocol
•HTS-friendly screening platform with Z' factor of > 0.83
•Miniaturizable assay reduces your cell culture costs

HitHunter™ cAMP GPCR assays allows you to obtain true Hits faster using a chemiluminescent, competitive immunoassay format. Read more »

Want to confirm your second messenger hits with a G-protein independent platform? Introducing EasyScreen™ β-Arrestin GPCR Assays

•Thaw, plate and get results from a focused screen in 24 hours
•Determine multiple pharmacologies in live cells without cell culture or assay development
•Simple, single addition chemiluminescent protocol
•HTS-friendly, assay-ready screening platform minimizes variability

EasyScreen β-Arrestin GPCR assays allow you to confirm hits using an alternate non-G-protein mediated screening platform. Read more »

Identify Receptor: Ligand Pairings Using the First-In-Class PathHunter™ β-Arrestin Orphan GPCR Technology

•Simple, homogeneous assay format ideal for HTS
•Deorphanize a receptor in a single day using our convenient Assay-Ready express format
•Universal, non-G-protein mediated signaling pathway
•Demonstrated success in identifying receptor:ligand pairings
•Ideal for surrogate ligand discovery, de-orphanization and profiling

Access the PathHunter β-Arrestin Orphan GPCR technology through a variety of convenient formats. Read more »

Calcium and cAMP Screening & Profiling Services

Because we understand the pressure to meet deadlines, DiscoveRx is committed to providing solutions for your screening and profiling needs. With over 30 native Gq coupled cell lines and
70 cAMP Hunter cell lines, we have the largest selection of naturally coupled cell-based assays
for second messenger detection. The process is simple. Send in your compounds, we perform
the work and deliver the data to you in 4 weeks or less. Get ahead with DiscoveRx Services
and start moving compounds faster into the clinic!

•View calcium response in native Gq-coupled PathHunter cell lines
•View cAMP response in native Gi/Gs cAMP Hunter cell lines.

Promotion Available!