1.866.448.4864
DiscoveRx: Kinase Screening & Profiling Services

PRODUCTS & SERVICES

Kinases

– Screening & Profiling Services: Information that drives decision making

Kinase Screening & Profiling Services


PathHunter™ Cell-Based Kinase Assays

Utilizing PathHunter™ technology, DiscoveRx has found a new approach to studying receptor tyrosine kinases in a cellular context. Unlike biochemical assays that commonly use a truncated version of the receptor, PathHunter™ Cell-Based Kinase assays utilize wild type, full length proteins which allow all steps in receptor activation be monitored. This whole cell assay platform is ideal for identifying novel receptor tyrosine kinase inhibitors, allosteric modulators or antibody therapeutics.

Receptor Tyrosine Kinase Panel

We currently have 13 receptor tyrosine kinase targets available for profiling, screening, and selectivity studies. We are continuing to develop additional targets in order to provide the most comprehensive panel.

Target
Partner Protein
Cell Line
Dose Curve
ErbB2/ErbB3
Grb2
U2OS
ErbB4
SHC1
U2OS
FGFR4
PLCG2
U2OS
Flt3
P85
U2OS
IGF1R
SHC1
1321N1
INSR
PLCG1
U2OS
PDGFRb
PLCG1
U2OS
TrkA
SHC1
U2OS
TrkA-P75
SHC1
U2OS
TrkB
SHC1
U2OS
TrkB-P75
SHC1
U2OS
TrkC
SHC1
U2OS
TrkC-P75
SHC1
U2OS

Click here to request a quote.

 

Copyright ©2009, DiscoveRx Corporation. TERMS AND CONDITIONS

Contact Us  |   Privacy Policy  |   Site Map  |   Careers