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GPCRs
DiscoveRx® offers an industry leading portfolio of over 400 non-force coupled GPCR cell lines designed to detect GPCR signaling through second messenger activation, arrestin binding and receptor internalization. Access to the same GPCR target in different technology formats allows multiple signaling pathways to be assayed in parallel using the same robust, reliable and high throughput friendly chemiluminescent format. Using a combination of all 3 technology platforms enables the identification of G-protein or Arrestin biased ligands and provides a unique opportunity to uncover novel compound pharmacology.
Available GPCR Assay Formats:
Click here to view all available targets!
New! Search GPCR products by family:
| Acetylcholine |
Class A Orphans | Glycoprotein Hormone Receptor |
Neuropeptide B & W | PTH receptor |
| Adenosine | Class B Orphans | Gonadotrophin-releasing Hormone Receptor | Neuropeptide F | Relaxin |
| Adrenoreceptor | Liganded Orphans | Histamine | Neuropeptide Y | Secretin |
| Anaphylotoxin | Corticotropin | Hydroxycarboxylic Acid | Neurotensin | Serotonin |
| Angiotensin | Dopamine | KISS1-derived Peptide Receptor |
Nicotinic Acid | Somatostatin |
| Apelin | Eicosanoid Receptor | Leukotriene | Opioid | Succinate Receptor |
| Bile Acid Receptors | Endothelin | Luteneizing Hormone | Orexin | Tachykinin |
| Bombesin | Formylpeptide | Lysophospholipid | P2Y | TRH |
| Bradykinin | Free Fatty Acid | Melanin-Concentrating Hormone Receptor |
Plate-activating factor | Urotensin |
| Calcitonin | Galanin | Melanocortin | Prokineticin | Vasopressin |
| Cannabinoid | Ghrelin | Melatonin | Prolactin Releasing Peptide Receptor | VIP & PACAP |
| Chemokine | Glucagon | Motilin | Prostanoid | |
| Cholecystokinin | Glutamate | Neuromedin U | Protease activated |
Access our technology in a variety of convenient formats including validated clonal cell lines, Assay-Ready products, or parental cell lines and expression vectors to support your in-house GPCR drug discovery. If you want our experts to work for you, we also offer custom assay development as well as screening and profiling services.
Download our Druggable GPCRome Poster today!
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