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Custom Assays, GPCRS Assays, Biochemical Assays-DiscoveRx

PRODUCTS & SERVICES

GPCR

- Custom Assay Development

Custom Assay Development


We'll Build EFC Assay Tools to Meet Your Needs

Our innovative technology has been successfully applied to many target areas in discovery research.  Custom projects utilize DiscoveRx’s proprietary EFC technology and span both biochemical assays, as well as, functional cell-based assays.

HitHunter® Biochemical Assays
Kinase Binding Assays

Conjugate the small fragment of ß-Gal (ED) to your inhibitor
Characterize and validate binding of an inhibitor to your kinase

Protease Assays
Develop protease substrates using up to 25 amino acids
EFC results are independent of peptide length - unlike FRET-based assays

PathHunter® Cell-Based Assays
β-Arrestin GPCR Assays

Direct assay of ligand binding to GPCR
Universal assay for all GPCR's regardless of G-protein coupling
Ideal for deorphanization programs

Nuclear Hormone Receptor (NHR) Assays
Two formats available: Nuclear translocation and Coactivator recruitment
Multiplex cell lines with both EFC and reporter gene assays in the same cell

Receptor Tyrosine Kinase (RTK) Assays
Functional cell-based kinase assay
Based on recruitment of SH2 domain proteins

cAMP Hunter™ GPCR Assays
Validated cell lines expressing Gi and Gs receptors
Designed for use with any cAMP detection kit

Don't see your assay?
Contact us at CAD@discoverx.com to discuss your assay needs.

 

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