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DiscoveRx: GPCRs - Assay-Ready Live Cell GPCR Kits

PRODUCTS & SERVICES

GPCR

- Assay-Ready

Assay-Ready Live Cell GPCR Kits





PathHunter™ and cAMP Hunter™ eXpress GPCR Assays allow you to measure one or multiple GPCR responses to compound challenge without having to invest in clonal cell lines. The kits come ready to use, include all the necessary detection reagents, media and plates and do not require expensive instrumentation to run.
By eliminating lengthy, expensive and time consuming cell culture, assay-ready GPCR kits enable interrogation of multiple GPCR targets and lead compounds in only a few hours. Simply thaw and plate the pre-validated cells and use directly for profiling, target prioritization or lead optimization.

Product Features

Off-the-shelf complete kit format
Pre-validated cells and reagents
Fast and easy step-by-step protocol
Assay-Ready frozen cells
Read on any standard benchtop luminometer

New! LumiLITE™ Microplate Reader

Introducing the LumiLITE™ Microplate Reader, a cost effective, 96-well bench top luminometer ideal for use with all PathHunter and cAMP Hunter eXpress GPCR Assay. Learn More»

EasyScreen™ β-Arrestin GPCR Assays provide a fast and easy method for performing small screens on a variety of lead compounds, peptides or natural ligands without lengthy and time consuming cell culture. Each EasyScreen assay is offered in a HTS-friendly, 384-well format. Kits include assay-ready frozen cells packaged in single use vials, assay buffer and chemiluminescent detection reagents. Simply thaw and plate the cells, and run the screen 24 hours later.

96-well eXpress Format
PathHunter™ eXpress
β-Arrestin GPCR
Assays
Monitor GPCR activity by direct measurement of ligand-induced β-Arrestin binding to the GPCR of interest.  Choose from over 120 human GPCR targets (Gi-, Gs-, and Gq-coupled) allowing pharmacologic confirmation of compounds in less than 3 hours. Read More»
PathHunter™ eXpress
β-Arrestin Ortholog
GPCR Assays
Determine effective dosing of compounds prior to expensive animal models. Choose from over 30 Ortholog GPCR targets. Read More»
PathHunter™ eXpress
β-Arrestin Orphan
GPCR Assays
Our universal β-Arrestin assay technology combined with the proven reliability and convenience of the eXpress platform offer a unique and novel tool for investigating Orphan GPCRs. Choose from 70 Orphan
GPCR targets. Read More»
cAMP Hunter™ eXpress
GPCR Assays
Unlike other force-coupled technologies, cAMP Hunter eXpress cells utilize the natural coupling status of the GPCR to monitor activation of difficult to rescue Gi- and Gs-coupled receptors. Choose from over 56 human GPCR targets. Read More»
384-well EasyScreen Format
EasyScreen™ Assays
Confirm hits from a Calcium or cAMP screen using this first in class, assay-ready screening product. Choose from over 150 human and ortholog GPCR targets and eliminate lengthy and time consuming cell culture and assay development forever. Read More»

 

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