Assay-Ready GPCR Kits
Ready-to-use complete kits for:
• Profiling of lead compounds
• Selectivity and specificity panels
• Antibody screening
• Biomarker detection in blood and plasma
• Compound dosing prior to animal studies
Now you can access our extensive menu of over 400 functional, whole cell GPCR
assays without having to invest in a clonal cell line. Our PathHunter® and
cAMP Hunter™ eXpress GPCR assays are ready-to-use complete kits that contain all the
necessary reagents to perform a functional whole cell assay including frozen pre-validated
cells, detection reagents, media and plates and do not require expensive instrumentation to
run. Eliminate lengthy, expensive and time consuming cell culture. Simply thaw, plate and
run the assay!
cAMP Hunter™ eXpress GPCR Assays provide a fast
and simple assay for detection of second messenger signaling for even the most difficult GPCR targets.
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PathHunter® eXpress β-Arrestin GPCR Assays provide
a direct measure of GPCR activation by monitoring β-Arrestin binding to the GPCR of interest
and can be used with any Gi-, Gq-, Gs-coupled receptor. Assays are available for known and
orphan GPCRs and non-human ortholog receptors Learn more»
New! PathHunter® eXpress GPCR Internalization Assays are
a non-imaging, non-antibody based platform that provides a quantitative measure of internalized
GPCR localized to the early endosome. Learn more»
Do you have a panel of mutant GPCRs you'd like to study?
Find out how you can build your own on demand GPCR assay in
just 3 simple steps with the new
PathHunter® GPCR Explorer Kit! Learn More»
PathHunter® eXpress β-Arrestin Format (96-well)
Monitor GPCR activity by direct measurement of ligand-induced β-Arrestin
binding to the GPCR of interest. Choose from over 120 human GPCR targets (Gi-, Gs-,
and Gq-coupled) allowing pharmacologic confirmation of compounds in less than 3 hours.
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Determine effective dosing of compounds prior to expensive animal models.
Choose from over 30 Ortholog GPCR targets.
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Our universal β-Arrestin assay technology combined with the proven
reliability and convenience of the eXpress platform offer a unique and novel tool for investigating
Orphan GPCRs. Choose from 70 Orphan GPCR targets.
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Identify novel functional antagonists or super agonists by direct and quantitative measurement of internalized GPCR protein localized to early endosomes.
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Build your own β-Arrestin recruitment assay and monitor GPCR activity
for any GPCR of your choice in just 3 simple steps making it ideal for
GPCR heterodimerization, siRNA knockdown, or mutant receptor studies.
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cAMP Hunter™ eXpress Format (96-well)
Unlike other force-coupled technologies, cAMP Hunter eXpress cells utilize
the natural coupling status of the GPCR to monitor activation of difficult to rescue Gi- and Gs-coupled
receptors. Choose from over 56 human GPCR targets.
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EasyScreen™ Format (384-well)
Confirm hits from a Calcium or cAMP screen using this first in class,
assay-ready screening product. Choose from over 120 human GPCR targets and eliminate lengthy and time consuming cell culture and assay development forever.
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Determine specificity of your lead compound in less than 3 hours. Choose from over 28 ortholog GPCR targets.
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