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PathHunter® β-Arrestin Overview*
GPCR stimulation results in both G-protein dependent second messenger activation and G-protein independent signaling events such as Arrestin recruitment and internalization. Quantitatively examining the complex relationship that exists between G-protein and β-Arrestin signaling determines both efficacy and potential side effects of GPCR-targeted drugs.
DiscoveRx now offers the largest menu of pre-validated Arrestin GPCR assays for both known and orphan GPCRs. Because Arrestin recruitment occurs independent of G-protein coupling, the PathHunter® β-Arrestin GPCR assays offer a powerful and universal screening and profiling platform that can be used with virtually any Gi-, Gs-, or Gq-coupled receptors.
Product Features
Naturally coupled Known (Human and Ortholog) and Orphan GPCR assays
Universal, G-protein independent read-out ideal for receptor de-orphanization
Simple, single reagent addition protocol
Superior assay windows and robust performance (Z' > 0.6)
Chemiluminescent detection
HTS-friendly format, easily miniaturizable
Available PathHunter® β-Arrestin GPCR Assays
GPCR Cell Lines
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Cell Lines
Assay Ready Products
Detection Reagents
Certified Reagents
*Covered by Issued and Pending patents. Limited Label License Conditions apply. Click here to learn more.
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