In this issue:
• Recent Developments
• Special Offers
• Presentations and Publications
• Announcements and Conferences
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Recent Developments - PathHunter™ Assays:
Choose from Over 50 PathHunter™ ß-Arrestin Assays for Screening Gi, Gs, or Gq GPCRs.
DiscoveRx now offers over 50 PathHunter ß-Arrestin Cell Pools and provides custom PathHunter ß-Arrestin services. Click here to request more information on the targets validated or to request a seminar or on-site demonstration.
Measure Nuclear Receptor Translocation In Vivo
PathHunter™ Nuclear Translocation Assays measure the effects of compounds on the nuclear translocation of a drug target in vivo. Four ready-to-use cell lines expressing nuclear hormone receptors are now available, including the Androgen Receptor, Liver X Receptor alpha, Vitamin D Receptor, and Glucocorticoid Receptor. We also offer 12 nuclear hormone receptor expression vectors, a cloning vector, and three parental cell lines for PathHunter Nuclear Translocation Assay development.
The homogeneous formats and simple protocols facilitate cost-effective, high-throughput screening, because they use microtitre plates and neither imaging or antibodies. Click here to learn more about PathHunter Protein Trafficking Assays.
Recent Developments - Kinase Assays:
Just Released: ADP Quest HS and ADP Hunter HS Assays - High sensitivity ADP accumulation assay kits that enable you to measure as little as 0.3 uM ADP!
• Generic, gain-of-signal assay
• Any substrate, no label required
• Kinetic and endpoint read mode
• High S/B and Z'
• Flexible [ATP] and [kinase] - ideal for low activity kinases
• Only commercial kinetic assay that can be run at constant [ATP]
Please contact your local DiscoveRx sales representative to discuss which assay is right for you or to request an evaluation.
Special Offers:
20% off ADP Quest HS or ADP Hunter HS Assay kit with mention of this newsletter. Offer expires March 30, 2007.
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Visit us at SBS or AACR and register for a chance to win a New iPod Shuffle!
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Posters and Presentations of DiscoveRx Technology:
Ultra High Throughput Screening for Gi antagonists: comparison of DiscoveRx HitHunter™ cAMP Assay with Lance and HTRF. Merck, 2006
Evaluation of a homogeneous approach for the identification of kinase inhibitors, using ß-galactosidase (ß-Gal) enzyme fragment complementation (EFC) assay, Pirthipal Singh, AstraZeneca. Screening Europe, Feb 20-21, 2007.
Comparison of Signal-independent Assay Technologies to Second Messenger Assays for Measuring G protein-coupled receptor Pharmacology in a Miniaturized 2 ul Ultra High Throughput Screening Format, Pirthipal Singh, Merck. Society for Biomolecular Sciences (SBS), April 15-19, 2007.
Identifying and Characterizing Cannabinoid CB2 Receptor Ligands using DiscoveRx PathHunter™ ß-Arrestin Assay, Schering-Plough Research Institute. Society for Biomolecular Sciences (SBS), April 15-19, 2007.
Development of a generic, homogeneous GPCR screening technology based on EFC complementation between ß-Arrestin and the target GPCR,DiscoveRx. Society for Biomolecular Sciences (SBS), April 16, 2007.
Increased Sensitivity and Performance in a General Purpose Kinase Screening and Profiling Technology Based on Detection of ADP Accumulation,DiscoveRx. Society for Biomolecular Sciences (SBS), April 17, 2007.
Applications of EFC-based Protein-Protein Interaction Assays to the Analysis of Gi, Gs, and Gq-coupled GPCR Screening, DiscoveRx. Society for Biomolecular Sciences (SBS), April 15-19, 2007.
A Rapid Non-Imaging, Non-Reporter Gene Screening Assay Format for Analysis of Nuclear Receptor Function in Whole Cells, DiscoveRx. Society for Biomolecular Sciences (SBS), April 15-19, 2007.
Optimized ADP accumulation assays for kinase primary screening and kinase and inhibitor characterization, Linnea Hager, DiscoveRx. Society for Biomolecular Sciences (SBS), April 15-19, 2007.
Please visit us at:
American Association for Cancer Research (AACR)
Booth #1847 - Register to win a New iPod Shuffle!
Los Angeles, CA
April 14-18, 2007
Society for Biomolecular Sciences (SBS)
Booth #1104 - Register to win a New iPod Shuffle!
Montreal, CN
April 15-19, 2007
British Pharmacological Society
Leicester, UK
April 16-17, 2007
World Pharmaceutical Congress
Booth #104
Philadelphia, PA
June 12-13, 2007
DiscoveRx – Simple Solutions for Complex Biology
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