In this issue:

• Recent Developments
• Special Offers
• Presentations and Publications
• Announcements and Conferences
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Recent Developments - New! PathHunter™ ß-Arrestin-GPCR Assays:

Over 90 PathHunter™ ß-Arrestin Assays for Screening Gi, Gs, or Gq GPCRs. View pharmacology data or request a seminar or on-site demonstration.

• GPCR screening without forced coupling for clean pharmacology
• Large assay windows provide increased confidence in results
• G-Protein-coupling independent-ideal for orphan receptors

New! PathHunter™ Assay Ready Products

Bulk Frozen PathHunter™ Cells, Pharmacologically Tested and Ready to Use in Several Convenient Formats

New! PathHunter™ Flash Detection Kit:

Cellular Assay Results in 30 seconds - No More Overnight Reporter Gene Assays

• Ultra-fast read times for HTS with fewer off-target effects
• Cell biology results in real time
• Compatible with FLIPR^TETRA , Hamamatsu FDSS 6000 and other Flash Readers
• Ability to multiplex with calcium assays

Figure 2. Analysis of GPCR Activity Using Flash on the FLIPRTETRA. A PathHunter™ ß-Arrestin Cell Line measures Cholecystokinin A (CCKAR) activation.

New! PathHunter™ Secretion Detection Kit:

Detect Expressed ProLabel-tagged Proteins Secreted into Culture Media

New! PathHunter™ U2OS Mitotic Index Cell Lines:

Screen Compound or siRNA Libraries to Identify Novel Cancer Therapeutics

New! Over 50 PhosphoQuest™ ELISA Kits for quantitating kinase activity in cells, lysates and tissue

• Quantitative
- measure phosphorylation-site specific proteins
- Recombinant standards included

• Sensitive
- detect using as few as ~4,000 cells
- 2-10x more sensitive than Western Blot

• Fast
- results in only half a day
- 20 minutes hand-on time

• Flexible
- sample size- 96-well-strip-well plates to screen larget or small sample sizes

• Easy-to-use
- kit contains all reagents needed

For more information on PhosphoQuest™ Kinase assays, please contact us at info@discoverx.com.

Special Offers:

Universal ADP accumulation assays for kinases and ATPase's at pennies per well!!! Contact info@discoverx.com and we will make it happen for you!

Homogeneous & Generic ADP Accumulation Assays for measuring Kinase and ATPase activity

• ATP is generated during assay, enabling accurate Michaelis-Menten kinetics
• No antibodies or labeled substrates required
• Suitable for peptide and whole protein substrates
• Tolerates a broad range of ATP concentrations
• Endpoint or kinetic protocols available
• Complete customer support, optimization guide and checklist for yor success

Now through September 30th, take advantage of our special offer:

• ADP Hunter™ HS and ADP Quest™ HS - 50% off (800 dp kit. One kit limit)

Download a tutorial on the assays:

Development of a generic, homogeneous GPCR screening technology based on EFC complementation between ß-Arrestin and the target GPCR.

For more information on all ADP assays or to take advantage of this special offer, please contact us at info@disocverx.com. Reference code ADP50

Posters and Presentations of DiscoveRx Technology:

Using Ligand-Induced Conformational Change to Screen for Compounds Targeting G-Protein-Coupled Receptors, B. F. O'Dowd, M. Alijaniaram, X. Ji, T. Nguyen, R. M. Eglen, and S. R. George, SBS Online.

Please visit us at:

NIH Research Festival,
Booth # 418
Bethesda, MD
Sept. 27, 2007

Drug Discovery SBS & European LRIG
Nottingham, UK
Oct. 01, 2007

Biotechnica
Hannover, Germany
Oct. 9, 2007

Assays & Cellular Tagets (ACT)
San Diego, CA
Oct. 17-19

Molecular Targets & Cancer Therapeutics
San Francisco, CA
Oct. 22-26

 

DiscoveRx – Simple Solutions for Complex Biology