[EUROFINS GPCR SYMPOSIUM 2022] Ligand Characterization of Mas-Related GPCR-X2 via Cell-Based Assays: Implications in Safety Liability Tests
- File Name/Number:
- EUROFINS GPCR SYMPOSIUM
Mast cells are principal players in IgE-, and more recently, non-IgE-mediated anaphylactoid reactions or pseudo-allergic Adverse Drug Reactions (ADR). A wide range of ligands can activate mast cells owing to their multiple receptor expression profiles, and their characterization hence warrants closer study, especially into their safety pharmacological roles.