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SAFETYscan™ Ion Channel Services

Expanding our ion channel services to support safety pharmacology studies, we now offer SAFETYscan patch clamping service in addition to fluorescence ion channel assays. From manual patch clamp, the gold standard in ion channel work, to an automated platform, the SAFETYscan patch clamp service provides efficient and high quality electrophysiology test for off-target activity of compounds.


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Available Ion Channel Assays

+: Assay is available
 
Target Gene Fluoresence
Assay
Patch Clamping
(Manual or QPatch)
Assay Mode
hERG KCNH2 + + Inhibition of the cardiac IKr current
NaV1.5 SCN5A + + Inhibition of the cardiac INa current
KV7.1 / minK KCNQ1/KCNE1 Inquire + Inhibition of the cardiac IKs current
CaV1.2 CACNA1C / CACNB2 / CACNA2D + + Inhibition of the cardiac L-Type calcium current
CaV3.2 CACNA1H Inquire + Inhibition of the atrial ICa, T-Type Ca current
NaV1.7 SCN9A  Inquire + Inhibitor assay
NaV1.6 SCN8A Inquire + Inhibitor assay
TRPV1 TRPV1 (VR1)  Inquire + Agonist / PAM / NAM assay
NMDAR1/2A GRIN1  /GRIN2A  Inquire + Agonist / PAM / NAM assay
NMDAR1/2B GRIN1 / GRIN2B,  Inquire + Agonist / PAM / NAM assay
NMDAR1/2D GRIN1 / GRIN2D Inquire + Agonist / PAM / NAM assay
GABAA (α1β2g2)  GABRA1 / GABRB2 / GABRG2  + + Agonist / PAM / NAM assay
GABAA (α2β2γ2)  GABRA2 / GABRB2 / GABRG2 Inquire + Agonist / PAM / NAM assay
GABAA (α3β2γ2)  GABRA3 / GABRB2 / GABRG2  Inquire + Agonist / PAM / NAM assay
GABAA (α4β3d)  GABRA4 / GABRB3 / GABRD Inquire + Agonist / PAM / NAM assay
GABAA (α5β2γ2)  GABRA5 / GABRB2 / GABRG2 Inquire + Agonist / PAM / NAM assay
GABAA (α6β3d)  GABRA6 / GABRB3 / GABRD Inquire + Agonist / PAM / NAM assay
5HT3A HTR3A  + + Agonist / PAM / NAM assay
GlyRα3 GLYRA3  Inquire + Agonist / PAM / NAM assay
Kir2.1 KCNJ2 Inquire + Inhibition of potassium current
Kv4.3 / ChIP2 KCND3 / KCNIP2 Inquire + Inhibition of the cardiac Ito
HCN4 HCN4 Inquire + Inhibition of the cardiac Ifunny
KV1.1 KCNA1 Inquire + Inhibition of potassium current
KV1.2 KCNA2 Inquire + Inhibition of potassium current
KV1.3  KCNA3 Inquire + Inhibition of potassium current
KV1.4  KCNA4 Inquire + Inhibition of potassium current
KV1.5  KCNA5 Inquire + Inhibition of potassium current
KV1.6 KCNA6 Inquire + Inhibition of potassium current

PAM: positive allosteric modulator
NAM: negative allosteric modulator

hERG Patch Clamp Service


Cav1.2 Patch Clamp Service