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Wortmannin

Wortmannin is a naturally occurring steroid metabolite that potently inhibits phosphotidylinositol 3-kinases (PI3Ks, IC50=1-10nM). Also inhibits PLK1 (IC50=24nM), PLK3 (IC50=49nM), MTOR, DNAPK, PI4Ks, MLCK, and MAPK at higher concentrations. Helps enhance apoptotic effects by inhibiting the PI3K/Akt cascade and blocking the antiapoptotic effects of cytokines.

Catalog No. Size Price Quantity
92-1095 1 mg $165.00
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Description
Wortmannin
Compound Type
Antagonist
Storage
≤ -20◦C
Source
Synthetic
Cells were plated in a 384-well plate and incubated overnight at 37°C/5% CO₂ to allow the cells to attach and grow. Cells were then stimulated with a control compound, using the assay conditions described below. Following stimulation, signal was detected using the PathHunter Detection Kit according to the recommended protocol.