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TAE684

TAE684 (NVP-TAE684) is a synthetic potent and selective inhibitor of the kinase ALK (IC50=3nM) as well as FLT3 and TIE2 (IC50=3nM and 12nM, respectively). It is 100 times more selective for ALK than InsR, and is effective at inhibiting the NPM-ALK fusion protein responsible for survival and proliferation of anaplastic large-cell lymphomas (ALCLs).

Catalog No. Size Price Quantity
92-1185 5 mg $304.00

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Description
TAE684
Compound Type
Agonist
Storage
≤ -20◦C
Source
Synthetic
Cells were plated in a 384-well plate and incubated overnight at 37°C/5% CO₂ to allow the cells to attach and grow. Cells were then stimulated with a control compound, using the assay conditions described below. Following treatment, signal was detected using the InCELL Hunter Detection Kit according to the recommended protocol.