TAE684

TAE684 (NVP-TAE684) is a synthetic potent and selective inhibitor of the kinase ALK (IC50=3nM) as well as FLT3 and TIE2 (IC50=3nM and 12nM, respectively). It is 100 times more selective for ALK than InsR, and is effective at inhibiting the NPM-ALK fusion protein responsible for survival and proliferation of anaplastic large-cell lymphomas (ALCLs).

Catalog No. Size Price Quantity
92-1185 5 mg $379.00

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Description
TAE684
Compound Type
Agonist
Storage
≤ -20◦C
Source
Synthetic
The above data is a representative example from a Eurofins DiscoverX cell-based assay that uses this ligand.