SR 49059

SR 49059 is an orally active synthetic small molecule that is a potent and selective inhibitor of the arginine vasopressin (AVP) V1a-receptor (Ki=1.1-6.3nM). AVP is an important hormone for circulatory and water homeostasis, as well as renal hemodynamic alterations, water retention, and cardiac remodeling in congestive heart failure. SR 49059 shows promise in platelet aggregation inhibition and treatment of Raynaud's disease, dysmenorrhea, and tocolysis.

Catalog No. Size Price Quantity
92-1279 10 mg $609.00

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SR 49059
Compound Type
Cells were plated in a 384-well plate and incubated for at least 4 hours at 37°C/5% CO₂ to allow the cells to attach. Cells were then stimulated with a control compound, using the assay conditions described below. Following stimulation, signal was detected using the PathHunter Detection Kit according to the recommended protocol.