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RFRP-3 (Human)

RFRP-3 is an inhibitory hormone that is a homolog of the gonadotropin-inhibitory hormone (GnIH) and blocks release of gonadotropin from GnRH in the pituitary. Inhibits cAMP accumulation and progesterone production from FSH, LH, and forskolin in granulosa-lutein cells. Agonist of the G protein-coupled receptor 147 (GPR147 or NPFF1, IC50=0.7nM).

Catalog No. Size Price Quantity
92-1198 500 µg $249.00

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RFRP-3 (Human)
Compound Type
Cells were plated in a 384-well plate and incubated overnight at 37°C/5% CO₂ to allow the cells to attach and grow. Cells were then stimulated with a control agonist, using the assay conditions described below. Following stimulation, signal was detected using the PathHunter Detection Kit according to the recommended protocol.