Tumor necrosis factor alpha (TNFα) is an endogenous pyrogen cytokine that plays a key part in regulating immune cells, immume response to infection, and systemic inflammation. Also regulates cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. Is implicated in multiple autoimmune disorders due to its role in inflammation, including inflammatory bowel disease, rheumatoid arthritis, ankylosing spondylitis, and psoriasis. Agonist of TNF receptor 1 and 2.