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Recombinant Human 4-1BB-L

4-1BB-L, also called CD137L or TNFSF9 is a transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is involved in reverse signaling that induces apoptosis in T cells and cytokine secretion by monocytes. 4-1BB-L, the ligand for the co-stimulatory immune checkpoint receptor CD137/4-1BB, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. 4-1BB-L through the 4-1BB receptor induces CD4+ and CD8+ T cells to proliferate and secrete cytokines.

Catalog No. Size Price Quantity
92-1321 25 µg $501.00

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Recombinant Human 4-1BB-L
Compound Type
Cells were seeded in a 96-well plate, incubated at 37°C / 5% CO₂ followed by stimulation with a control ligand, as defined in the assay conditions below. After stimulation, assay signal was detected using the PathHunter® detection kit according to the recommended protocol.