Pergolide mesylate (trade name Permax) is a synthetic ergoline-based dopamine receptor agonist used for treatment of Parkinson's and hyperprolactinemia. Agonist of the dopamine D1,D2 and serotonin 5HT-1A,-1B,-2A,-2B,and -2C receptors, suppressing pituitary secretion of prolactin and increasing dopamine activity.