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Leukotriene C4

Leukotriene C4 is a pro-inflammatory cysteinyl leukotriene derived from arachidonic acid and produced from leukocytes in response to inflammation. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A), and is a potent agonist for the contraction of smooth muscle. Contributes to the pathogenesis of asthma and acute allergic hypersensitivity through bronchoconstriction and vascular permeability.

Catalog No. Size Price Quantity
92-1211 25 µg $820.00

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Description
Leukotriene C4
Compound Type
Agonist
Storage
-20°C
Source
Synthetic
Cells were plated in a 384-well plate and incubated overnight at 37°C/5% CO₂ to allow the cells to attach and grow. Culture media was removed and replaced with dye loading buffer from the Calcium No WashPLUS detection kit according to the recommended protocol. Target cells and native parental cells were stimulated with a control agonist and calcium mobilization was detected using a FLIPR® Tetra (Molecular Devices, Inc.).