GW 4064

GW 4064 is a synthetic small molecule selective agonist of the orphan nuclear receptor FXR (EC50=15nM) developed by GlaxoSmithKline. Protects cells and organs against bile acid toxicity, and used to elucidate FXR's role in dyslipidemia, diabetes, obesity, and cancer. Has no activity against other nuclear receptors.

Catalog No. Size Price Quantity
92-1129 10 mg $282.00

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GW 4064
Compound Type
Cells were plated in a 384-well plate and incubated overnight at 37°C/5% CO₂ to allow the cells to attach and grow. Cells were then stimulated with a control compound, using the assay conditions described below. Following stimulation, signal was detected using the PathHunter Detection Kit according to the recommended protocol.