CDDO Methyl Ester

CDDO Methyl Ester (bardoxolone methyl) is a semi-synthetic triterpenoid developed from the oleanolic acid scaffold that induces apoptosis and differentiation in tumor cells. Agonist of the KEAP1-Nrf2 pathway, thus inducing expression of antioxidant proteins and protection against oxidative damage from injury and inflammation. Also an antagonist of the NF-kB pro-inflammatory transcription factor. Clinical trials are currently underway for type 2 diabetes treatment, due to its potent antidiabetic activity, but was confirmed to enhance cardiac disease during a phase 2 trial in October 2012.

Catalog No. Size Price Quantity
92-1147 5 mg $252.00

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CDDO Methyl Ester
Compound Type
The above data is a representative example from a Eurofins DiscoverX cell-based assay that uses this ligand.