A-61603 hydrobromide

A 61603 is a synthetic small molecule and potent agonist of the G protein-coupled alpha 1A receptor (α1A), at least 35-fold selective vs α1B or α1D. More potent stimulant of phosphoinositide hydrolysis than norepinephrine, and inhibited by prazosin. Key role in modulation of the sympathetic nervous system, and increases spontaneous calcium transients more potently than phenylephrine. May be implicated in diseases such as hypertension.

Catalog No. Size Price Quantity
92-1230 10 mg $359.00

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A-61603 hydrobromide
Compound Type
Cells were plated in a 384-well plate and incubated overnight at 37°C/5% CO₂ to allow the cells to attach and grow. Cells were then stimulated with a control agonist, using the assay conditions described below. Following stimulation, signal was detected using the PathHunter Detection Kit according to the recommended protocol. Please refer to page 2 for recommended assay reagents, detection reagents, and control compounds.