(+)-JQ1

JQ1 is a chemical compound which is under development as a non-hormonal male contraceptive drug. Its chemical structure is a triazolothienodiazepine, a series originally discovered by Mitsubishi Pharma [WO/2009/084693], related to benzodiazepinederivatives such as etizolam, however JQ1 does not produce sedative or anxiolytic effects and is instead a potent and selective inhibitor of the bromodomain testis-specific protein BRDT, which is essential for chromatin remodeling during spermatogenesis.

Catalog No. Size Price Quantity
92-1149 1 mg $104.00

Please contact Customer Service at customerservicedrx@eurofins.com for European (EUR) or United Kingdom (GBP) pricing or log in to see your account-specific pricing.
Description
(+)-JQ1
Compound Type
Antagonist
Storage
≤ -20◦C
Source
Synthetic
Cells were plated in a 384-well plate and incubated overnight at 37°C/5% CO₂ to allow the cells to attach and grow. Cells were then stimulated with a control compound, using the assay conditions described below. Following treatment, signal was detected using the InCELL Hunter Detection Kit according to the recommended protocol.