N-terminal 6His-tagged, recombinant, human IRE2, amino acids 505-end.
IRE2 enables several functions, including ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. IRE2 is also involved in several processes, including apoptotic chromosome condensation; negative regulation of transcription, DNA-templated; and rRNA catabolic process. Predicted to be located in endoplasmic reticulum membrane and endoplasmic reticulum quality control compartment. Predicted to be integral component of membrane. Predicted to be part of IRE1-TRAF2-ASK1 complex. [provided by Alliance of Genome Resources, Apr 2022]