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PathHunter® U2OS TIM3/TIM3 Dimerization Cell Line

The PathHunter® Dimerization assay detects ligand induced dimerization of two subunits of a receptor-dimer pair. The cells have been engineered to co-express one receptor subunit fused to Enzyme Donor (ED), and a second dimer partner fused to Enzyme Acceptor (EA). Cytoplasmic tail may have been deleted from one or both receptor. Binding of an agonist to one receptor subunit induces it to interact with its dimer partner, forcing complementation of the two enzyme fragments. This results in the formation of a functional enzyme that hydrolyzes a substrate to generate a chemiluminescent signal.

Catalog No. Size Price Quantity
93-1082C3 2 vials $19995.00
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Related Family Members:

T-cell immunoglobulin mucin receptor 3
Receptor Family
T cell receptor (inhibitory)
Accession Number
Prolink™ Tag
Cell Background
Available as a Service?
Anti-TIM3 Antibody [344801]
  • [User Manual] PathHunter® Dimerization Assay

    PathHunter® Dimerization Assays provide a robust, highly sensitive and easy-to-use cell-based functional assay to study various protein activities in a cell. The assays allow for the monitoring of receptor-receptor interactions at the&...

    [User Manual] PathHunter® Dimerization Assay

Required Products

Cat. No. Description Size Price Quantity
93-0247 PathHunter® Flash Detection Kit 125 mL 1,000/4,000 dp (96-well/384-well) $3313.00
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92-3103G AssayComplete™ Cell Culture Kit-103 Kit $339.00
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93-0563R5A AssayComplete™ Cell Plating 5 Reagent 100 mL $299.00
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Recommended Products

Cat. No. Description Size Price Quantity
92-1313 Human TIM3 Antibody [344801] 25 µg $250.00
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92-0013 384-well Clear bottom TC Treated, Sterile WCB, FB w/ LID 10 plates/pk $179.00
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92-0015 384-well White bottom TC Treated, Sterile w/ LID 10 plates/pk $179.00
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