PathHunter® U2OS CD33 Internalization Cell Line

PathHunter Internalization Assays are cell-based assays that measure internalization of single-pass membrane receptors, e.g. receptor tyrosine kinases (ErbB-2), immune checkpoint receptors (CD33), mediated by small molecule or biologic therapeutics. Measuring drug-mediated receptor internalization can provide insight into diseases, drug tolerance, unwanted side effects and helps in identifying safer drugs. These receptor internalization assays are valuable tools for therapeutics that require internalization, which is used as a key determinant for their efficacy, such as for antibody-drug conjugates (ADCs). These assays utilize stable cell lines and a simple, homogenous protocol and can easily be implemented in a high-throughput format.

Catalog No. Size Price Quantity
93-1148C3 2 vials $20,599.00

For account specific pricing, please contact Customer Service at customerservicedrx@eurofins.com.

Related Family Members:

Receptor Family
IgSF (immune inhibitory receptor)
Accession Number
NM_001772.3
Species
Human
Prolink™ Tag
PK1
Cell Background
U2OS
Agonist/Ligand
Anti-CD33 Antibody
  • [User Manual] PathHunter® Internalization Assays

    PathHunter Internalization Assays are cell-based assays that measure internalization of single-pass membrane receptors, e.g. receptor tyrosine kinases (ErbB-2), immune checkpoint receptors (CD33), mediated by small molecule or biologic therapeutics. Measuring drug-mediated receptor internalization can provide insight into diseases, drug tolerance, unwanted side effects and helps in identifying ...

    [User Manual] PathHunter® Internalization Assays