ChemiScreen™ CCR8 Chemokine Receptor Stable Cell Line

CCR8 is a GPCR that binds primarily to the chemokine I-309 (CCL1) (Roos et al., 1997). CCR8 is expressed primarily on Th2 cells although its functional role in T cell recruitment to sites of allergic inflammation is controversial (Chensue et al., 2001; Goya et al., 2003). CCR8+ T-cells are abundant in skin, and rare or absent in the GI tract and peripheral blood, indicating a role in skin-homing of T-cells (Schaerli et al., 2004). In addition, monocyte-derived dendritic cells express CCR8 and utilize CCR8 during mobilization from skin to the lymph node (Qu et al., 2004). The cloned human CCR8-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant CCR8 expression on the cell surface and contains high levels of the promiscuous G protein Gα15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for agonists, antagonists and modulators at CCR8.

Catalog No. Size Price Quantity
HTS013C 2 Vials $18,779.00

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Application
Calcium Flux Assay
Family
Chemokine
Target
CCR8
Accession Number
U45983
Species
Human
Host Cell Type
Chem-1
Content
2 Vials of mycoplasma-free cells, 1 ml per vial
Storage
Cell vials are to be stored in the vapor phase of liquid N2.
  • [User Manual] ChemiSCREEN™ and ChemiBRITE™ Cell Lines

    The ChemiSCREEN and ChemiBRITE Cell Lines are designed to enable the measurement of intracellular calcium levels when a GPCR of interest has been activated by a ligand. These cell lines are suitable for studying small molecules as well as biologics. The assay protocol has been optimized for use in either a 384-well or 96-well format.

    ChemiSCREEN and ChemiBRITE cells stably expres...

    [User Manual] ChemiSCREEN™ and ChemiBRITE™ Cell Lines