PrecisION® hGABAA α6/β3/γ2 Recombinant Stable Cell Line

Gamma-aminobutyric acid (GABA)-gated ion channels are widely distributed in the mammalian brain and are major mediators of inhibitory synaptic transmission. A typical GABA ion channel has a pentameric structure consisting of 5 protein subunits, often α, β and γ or δ, combining to form a central ion conducting pore across the cell membrane. In humans there are six genes that encode α subunits, three that encode β, three that encode γ, and an additional seven genes that encode other subunits whose function is less-well understood than the α, β and γ subunits. GABA ion channels open and close in response to secretion of GABA from presynaptic terminals. GABAA α6 channels are typically comprised of α6, β2 or β3, and γ2 subunits and this combination is preferentially expressed in the mammalian cerebellum in granule cells (Mohler & Rudolph 2004). GABAA α6-containing receptors are located synaptically and comprise <5% of all GABAA receptors located in the brain. These receptors are insensitive to benzodiazepines.

Catalog No. Size Price Quantity
CYL3086 2 Vials Inquire

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Application
Electrophysiology assay (Conventional and automated patch clamp platforms)
Family
Chloride, Ligand-Gated
Target
GABAA α6/β3/γ2
Accession Number
NM_000811; NM_000814; NM_000816
Species
Human
Host Cell Type
HEK 293
Content
2 Vials of mycoplasma-free cells, 1 mL per vial aliquots containing 2M to 4M cells/mL in DMSO
Storage
Vials are to be stored in vapor phase of liquid N2