Kv2.1 is mostly expressed in the hippocampus and cortex in pyramidal neurons in the brain. It is a delayed rectifier K+ current that contributes to excitability, action potential duration and tonic spiking. Kv9.2 is found in excitable and non-excitable cells. These two channels are often combined and help regulate each other’s kinetics via the alpha subunits. Both are in the Shab-related subfamily of potassium channels.