PrecisION® hCav2.2 α1B/β3/α2δ1 Recombinant Stable Cell Line

hCav2.2-α1B is a voltage-gated calcium channel alpha subunit. It is expressed almost exclusively in neurons typically located at high densities in presynaptic terminals. Opening of these channels enables the rapid influx of the extracellular Ca2+, triggering exocytotic vesicle fusion with terminal membranes and subsequent neurotransmitter release. Evidence suggests that Cav2.2 channels have a fundamental role in instigating increased excitability and neurotransmitter release in various pain syndromes. The link between Cav2.2 and pain neurotransmission in humans has been further vindicated by the effectiveness of PrialtR (ziconotide), a synthetic version of ω -conotoxin MVIIA, in treating severe chronic pain.

Catalog No. Size Price Quantity
CYL3054 2 Vials Inquire

Please contact Customer Service at customerservicedrx@eurofins.com for European (EUR) or United Kingdom (GBP) pricing or log in to see your account-specific pricing.

Related Family Members:

Application
Electrophysiology assay (Conventional and automated patch clamp platforms)
Family
Calcium, Voltage-Gated
Target
Cav2.2
Accession Number
NM_000718
Species
Human
Host Cell Type
HEK 293
Content
2 Vials of mycoplasma-free cells, 1 mL per vial aliquots containing 2M to 4M cells/mL in DMSO
Storage
Vials are to be stored in vapor phase of liquid N2