PrecisION® hHCN3 Recombinant Stable Cell Line

Four different hyperpolarization-activated, cyclic nucleotide-modulated (HCN) channel isoforms have been cloned (HCN1-4). They can be distinguished by differing sensitivity to modulators such as cAMP, different V½ values of activation and different activation kinetics. Even though they are structurally similar to Kv channels they are activated by strong hyperpolarizing voltages rather than depolarizing voltages. As such the channels are active at or around the resting potential and contribute to pacemaker activity both in the heart and CNS. There is considerable overlap in the expression of these isoforms in different tissues (Moosmang et al., 2001, Stieber et al., 2005) and it is highly likely that they can form heteromultimers (Altomare et al., 2003, Chen et al., 2001, Brewster et al., 2005). Altered HCN channel expression has been implicated in increased neuronal hyperexcitability following seizures and may represent a novel drug target for the treatment of seizure-evoked epilepsy (Brewster et al., 2005). HCN channels also appear to have a role in some models of neuropathic pain where the spontaneous firing of damaged nerves and therefore the sensation of pain can be alleviated by the selective HCN blocker ZD7288 (Chaplan et al., 2003).

Catalog No. Size Price Quantity
CYL3042 2 Vials Inquire

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Electrophysiology assay (Conventional and automated patch clamp platforms)
HCN, Hyperpolarized
Accession Number
Host Cell Type
HEK 293
2 Vials of mycoplasma-free cells, 1 mL per vial aliquots containing 2M to 4M cells/mL in DMSO
Vials are to be stored in vapor phase of liquid N2