PrecisION® hKir2.1 Recombinant Stable Cell Line

Kir2.1 has a fundamental role in controlling the resting potential of cardiac myocytes and shaping the cardiac action potential. It is therefore likely that drugs affecting this channel will have an effect on cardiac excitability. Mutations in the KCNJ2 gene that encodes Kir2.1, reduce expression of the channel and cause a form of long QT syndrome (Andersen Syndrome, LQT7) that predisposes individuals to ventricular arrhythmias.Recognition that the dysfunction of this channel can lead to long QT has lead to it’s inclusion into the cardiac panel.

Catalog No. Size Price Quantity
CYL3032 2 Vials Inquire

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Application
Electrophysiology assay (Conventional and automated patch clamp platforms)
Family
Potassium, Inward Rectifier
Target
Kir2.1
Accession Number
NM_00891
Species
Human
Host Cell Type
HEK 293
Content
2 Vials of mycoplasma-free cells, 1 mL per vial aliquots containing 2M to 4M cells/mL in DMSO
Storage
Vials are to be stored in vapor phase of liquid N2