PrecisION® hKCNQ1/hminK Recombinant Stable Cell Line

KCNQ1 and mink form the slow delayed rectifier potassium current, IKs in the heart. This multimeric ion channel contributes to cardiac action potential repolarization and determines the heartbeat rate. Mutations in either KCNQ1 or minK that reduce IKs have been shown to cause long-QT syndrome (LQTS), a disorder of ventricular repolarization that can result in cardiac arrhythmia and sudden death. A well-recognized potential treatment for LQTS caused by reduction of IKs is to enhance functional activation of cardiac KCNQ1/minK channels.

Catalog No. Size Price Quantity
CYL3007 2 Vials Inquire

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Application
Electrophysiology assay (Conventional and automated patch clamp platforms)
Family
Potassium, Voltage-Gated
Target
KCNQ1/hminK
Accession Number
AF000571
Species
Human
Host Cell Type
CHO-K1
Content
2 Vials of mycoplasma-free cells, 1 mL per vial aliquots containing 2M to 4M cells/mL in DMSO
Storage
Vials are to be stored in vapor phase of liquid N2