PathHunter® Jurkat ICOS Signaling Cell Line

The PathHunter ICOS Checkpoint Signaling cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting signaling checkpoints. This cell line enables assessment of ligand (e.g. ICOS-L) based activation of ICOS receptors via detection of SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged ICOS target protein and EA-tagged SH2 domain protein. Upon activation of the receptor by its ligand or an agonist antibody, recruitment of SH2 domain protein to the phosphorylated receptor tail leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.

Catalog No. Size Price Quantity
93-1127C19 2 vials $36,669.00

For account specific pricing, please contact Customer Service at customerservicedrx@eurofins.com.

Related Family Members:

Receptor Family
IgSF (immune co-stimulatory receptor)
Coupling
N/A
Accession Number
NM_012092.3
Species
Human
Prolink™ Tag
PK1
Cell Background
Jurkat
Agonist/Ligand
Anti-ICOS antibody

Please refer to the datasheet above for a complete list of required and recommended products.

Select Required Products

Cat. No. Description Size Price Quantity
93-0933 PathHunter® Bioassay Detection Kit 75 mL (1,000 dp, 96-well) $4,659.00
92-3101G AssayComplete™ Cell Culture Kit-101 Kit $349.00
92-5105FR AssayComplete™ Freezing Reagent F5 2 x 50 mL $299.00
93-0563R0A AssayComplete™ Cell Plating 0 Reagent 100 mL $299.00
92-4106TR AssayComplete™ Thawing Reagent T6 100 mL $239.00
92-0029 AssayComplete™ Hygromycin B 20 mL $179.00
92-0030 AssayComplete™ G418 20 mL $139.00