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PathHunter® Jurkat CTLA4 Signaling Assay

Checkpoint Signaling assays are engineered to co-express a ProLink™ (PK) tagged immune checkpoint receptor and an Enzyme Acceptor (EA) tagged SH2 domain. Ligand engagement leads to receptor activation and phosphorylation, resulting in SH2-EA recruitment to the receptor, and forcing complementation of the two β-galactosidase enzyme fragments (EA and PK). The resulting functional enzyme hydrolyzes substrate to generate a chemiluminescent signal.


Catalog No. Size Price Quantity
93-1094C19 2 vials $35597.00
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Related Family Members:

Target/Description
Cytotoxic T-lymphocyte protein 4
Receptor Family
T cell receptor (inhibitory)
Coupling
N/A
Accession Number
NM_005214.4
Species
Human
Prolink™ Tag
PK1
Cell Background
Jurkat
Available as a Service?
No
Antagonist/Inhibitor
Anti-CTLA4 Antibody [14D3]

Required Products

Cat. No. Description Size Price Quantity
93-0933 PathHunter® Bioassay Detection Kit 50 mL (1,000 dp, 96-well) $4366.00
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92-3101G AssayComplete™ Cell Culture Kit-101 Kit $339.00
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93-0563R0A AssayComplete™ Cell Plating 0 Reagent 100 mL $299.00
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