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PathHunter® Jurkat CTLA4 Signaling Assay

Checkpoint Signaling assays are engineered to co-express a ProLink™ (PK) tagged immune checkpoint receptor and an Enzyme Acceptor (EA) tagged SH2 domain. Ligand engagement leads to receptor activation and phosphorylation, resulting in SH2-EA recruitment to the receptor, and forcing complementation of the two β-galactosidase enzyme fragments (EA and PK). The resulting functional enzyme hydrolyzes substrate to generate a chemiluminescent signal.

Catalog No. Size Price Quantity
93-1094C19 2 vials $35597.00

Related Family Members:

Receptor Family
T cell receptor (inhibitory)
Coupling
N/A
Accession Number
NM_005214.4
Species
Human
Prolink™ Tag
PK1
Cell Background
Jurkat
Antagonist/Inhibitor
Anti-CTLA4 Antibody [14D3]

Please refer to the datasheet above for a complete list of required and recommended products.

Select Required Products

Cat. No. Description Size Price Quantity
93-0933 PathHunter® Bioassay Detection Kit 50 mL (1,000 dp, 96-well) $4366.00
92-3101G AssayComplete™ Cell Culture Kit-101 Kit $339.00
93-0563R0A AssayComplete™ Cell Plating 0 Reagent 100 mL $299.00


Select Recommended Products

Cat. No. Description Size Price Quantity
92-0013 384-well Clear bottom TC Treated, Sterile WCB, FB w/ LID 10 plates/pk $179.00
92-0015 384-well White bottom TC Treated, Sterile w/ LID 10 plates/pk $179.00
92-0009 AssayComplete™ Cell Detachment Reagent 50 mL $89.00
92-0011 Green V-Bottom PP Ligand Dilution Plates 10 plates/pk $69.00