PathHunter® U2OS OX40 Signaling Cell Line

The PathHunter OX40 Checkpoint Signaling cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting signaling checkpoints. This cell line enables assessment of OX40 induced non-canonical NF-κB signaling via detection of NIK stabilization. This product uses EFC technology. The included cell line overexpresses ED-tagged NIK (NF-kappa-B Inducing Kinase) protein as well as untagged OX40 receptor. Upon activation of the receptor by its ligand or an antibody, NIK is stabilized, allowing detection of EFC signal when treated with exogenous EA. This stable modified cell line is provided as two vials of cryopreserved cells.

Catalog No. Size Price Quantity
93-1080C3 2 vials $37,039.00

For account specific pricing, please contact Customer Service at customerservicedrx@eurofins.com.
Receptor Family
Tumor Necrosis Factor Receptor Superfamily Receptor
Accession Number
NM_003327.3
Species
Human
Cell Background
U2OS
  • [User Manual] PathHunter® Checkpoint Assay - TNF Receptor Superfamily (TNFRSF)

    The PathHunter Checkpoint Signaling Assay for Tumor Necrosis Factor Receptor Superfamily (TNFRSF) members (or receptors) is a simple, highly specific assay to enable discovery and development of small molecule and biologic drugs targeting the TNFR superfamily of receptors that activate the non-canonical NF-kB pathway through NF-kB inducing kinase (NIK). The assay is a robust measurement of co-s...

    [User Manual] PathHunter® Checkpoint Assay - TNF Receptor Superfamily (TNFRSF)