PathHunter® Pertuzumab Bioassay Kit

The PathHunter Pertuzumab Bioassay Kit provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay asseses ligand (e.g. IL-6) based on activation of HER2 Kinase activity via detection of Dimerization. The included cell line overexpresses ProLink-tagged HER2 and EA-tagged . Activation of HER2 stimulates the recruitment of and produces EFC signal.This assay has been optimized and qualified with Perjeta (not supplied in the bioassay kit). Perjeta is a registered trademark of Genentech, Inc.. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates.

Catalog No. Size Price Quantity
93-1042Y3-00096 1000 dp (10 x 96-well) $8,259.00
93-1042Y3-00095 200 dp (2 x 96-well) $2,399.00

Please contact Customer Service at customerservicedrx@eurofins.com for European (EUR) or United Kingdom (GBP) pricing or log in to see your account-specific pricing.

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Target/Description
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2
Group
Receptor Tyrosine Kinase
Cell Background
U2OS
Receptor Species
Human
Accession Number
NM_004448.2
Agonist/Ligand
Recombinant Human Heregulin-β2
Antagonist/Inhibitor
Pertuzumab
Assay Measures
Dimerization
Bioassay Target Name
ErbB2/ErbB3
Assay Qualified With
Perjeta
Drug Trademark Owner
Perjeta is a registered trademark of Genentech, Inc.
Format
See User Manual for Product Configuration Details. The purpose of the control ligand included in the Bioassay Kit is for verification of assay performance relative to the data shown in the Certificate of Analysis for that kit. This control ligand is not intended for use as a reference standard for validation studies and lot release applications. Typically, a reference medicinal product (RMP) that has been pre-defined by the customer as an internal reference standard is used for those applications. The RMP is not provided with the bioassay kit or supplied by Eurofins DiscoverX.
Storage
Short term (<24 h): Store at -80°C; Long term (>24 h): Store in vapor phase of liquid nitrogen.
Coupling
N/A
  • [User Manual] PathHunter® Pertuzumab Bioassay Kit

    PathHunter Pertuzumab Bioassay kits provide a functional, robust, highly sensitive, and easy-to-use cell-based assay to study pertuzumab potency and neutralizing antibodies. The bioassay kits contain all the reagents needed for a complete assay including cells, detection reagents, cell plating reagent, positive control agonist, and assay plates. The pre-qualifi...

    [User Manual] PathHunter® Pertuzumab Bioassay Kit