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PathHunter® Pertuzumab Bioassay Kit

The PathHunter® Dimerization Bioassay detects ligand induced dimerization of two subunits of a receptor-dimer pair. The cells have been engineered to co-express one receptor subunit fused to Enzyme Donor (ED), and a second dimer partner fused to Enzyme Acceptor (EA). Cytoplasmic tail may have been deleted from one or both receptors. Binding of an agonist to one receptor subunit induces it to interact with its dimer partner, forcing complementation of the two enzyme fragments. This results in the formation of a functional enzyme that hydrolyzes a substrate to generate a chemiluminescent signal.

Catalog No. Size Price Quantity
93-1042Y3-00096 1000 dp (10 x 96-well) $8251.00
93-1042Y3-00095 200 dp (2 x 96-well) $2352.00

For account specific pricing, please contact Customer Service at customerservicedrx@eurofins.com.

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Target/Description
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2
Group
Receptor Tyrosine Kinase
Cell Background
U2OS
Species
Human
Accession Number
NM_004448.2
Agonist/Ligand
Recombinant Human Neuregulin-1 Beta 2
Antagonist/Inhibitor
Pertuzumab
Assay Measures
Dimerization
Bioassay Target Name
ErbB2/ErbB3
Assay Qualified With
Perjeta
Drug Trademark Owner
Perjeta is a registered trademark of Genentech, Inc.
Format
See User Manual for Product Configuration Details
Storage
Short term (<24 h): Store at -80°C; Long term (>24 h): Store in vapor phase of liquid nitrogen.
Coupling
N/A
  • [User Manual] PathHunter® Pertuzumab Bioassay Kit

    PathHunter Pertuzumab Bioassay kits provide a functional, robust, highly sensitive, and easy-to-use cell-based assay to study pertuzumab potency and neutralizing antibodies. The bioassay kits contain all the reagents needed for a complete assay including cells, detection reagents, cell plating reagent, positive control agonist, and assay plates. The pre-qualifi...

    [User Manual] PathHunter® Pertuzumab Bioassay Kit