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PathHunter® IL17RA/IL17RC Dimerization Bioassay Kit

The PathHunter IL17RA/IL17RC Dimerization Bioassay Kit provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay asseses ligand (e.g. IL-17 (IL-17A)) based on activation of IL17RA/IL17RC Cytokine activity via detection of Dimerization. The included cell line overexpresses ProLink-tagged IL17RA/IL17RC and EA-tagged . Activation of IL17RA/IL17RC stimulates the recruitment of and produces EFC signal. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates.

Catalog No. Size Price Quantity
93-0999Y3-00054 1000 dp (10 x 96-well) $8,975.00
93-0999Y3-00053 200 dp (2 x 96-well) $2,780.00
Please contact Customer Service at customerservicedrx@eurofins.com for European (EUR) or United Kingdom (GBP) pricing or log in to see your account-specific pricing.

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Target/Description
Interleukin-17 receptor A
Group
Interleukin Receptor
Cell Background
U2OS
Receptor Species
Human
Accession Number
NM_014339
Agonist/Ligand
IL-17 (IL-17A)
Assay Measures
Dimerization
Bioassay Target Name
IL17RA/IL17RC
Assay Qualified With
IL-17A
The following graph is an example of a typical dose-response curve for the IL17RA/IL17RC Dimerization Bioassay, generated using the protocol outlined in the user manual.
Format
See User Manual for Product Configuration Details. The purpose of the control ligand included in the Bioassay Kit is for verification of assay performance relative to the data shown in the Certificate of Analysis for that kit. This control ligand is not intended for use as a reference standard for validation studies and lot release applications. Typically, a reference medicinal product (RMP) that has been pre-defined by the customer as an internal reference standard is used for those applications. The RMP is not provided with the bioassay kit or supplied by Eurofins DiscoverX.
Storage
Short term (<24 h): Store at -80°C; Long term (>24 h): Store in vapor phase of liquid nitrogen.
Coupling
N/A

  • [User Manual] PathHunter® IL17RA/IL17RC Dimerization Bioassay Kit

    PathHunter IL17RA/IL17RC Bioassay Kits provide a robust, highly sensitive and easy-to-use, cell-based functional assay to study receptorreceptor interactions at the cell surface. The Bioassay kits contain all the reagents needed for a complete assay including cells, detection reagents, cell plating reagent, positive control agonist, and assay plates. The pre-validated, frozen bioassay cells hav...

    [User Manual] PathHunter® IL17RA/IL17RC Dimerization Bioassay Kit