cAMP Hunter™ Follitropin Alfa Bioassay Kit

The cAMP Hunter Follitropin Alfa Bioassay Kit provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay asseses ligand (e.g. PTH(1-34)) based on activation of FSHR GPCR activity via detection of cAMP. The included cell line overexpresses ProLink-tagged FSHR and EA-tagged . Activation of FSHR stimulates the recruitment of and produces EFC signal.This assay has been optimized and qualified with Gonal-F (not supplied in the bioassay kit). Gonal-F is a registered trademark of Merck KGAA. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates.

Catalog No. Size Price Quantity
95-0119Y2-00104 1000 dp (10 x 96-well) $8,259.00
95-0119Y2-00103 200 dp (2 x 96-well) $2,399.00

Please contact Customer Service at customerservicedrx@eurofins.com for European (EUR) or United Kingdom (GBP) pricing or log in to see your account-specific pricing.

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Target/Description
Follicle stimulating hormone receptor
Group
Glycoprotein hormone receptor
Cell Background
CHO-K1
Receptor Species
Human
Accession Number
NM_000145
Agonist/Ligand
FSH, Human
Assay Measures
cAMP
Bioassay Target Name
FSHR
Assay Qualified With
Gonal-F
Drug Trademark Owner
Gonal-F is a registered trademark of Merck KGAA
Format
See User Manual for Product Configuration Details. The purpose of the control ligand included in the Bioassay Kit is for verification of assay performance relative to the data shown in the Certificate of Analysis for that kit. This control ligand is not intended for use as a reference standard for validation studies and lot release applications. Typically, a reference medicinal product (RMP) that has been pre-defined by the customer as an internal reference standard is used for those applications. The RMP is not provided with the bioassay kit or supplied by Eurofins DiscoverX.
Storage
Short term (<24 h): Store at -80°C; Long term (>24 h): Store in vapor phase of liquid nitrogen.
Coupling
Gs
  • [User Manual] cAMP Hunter™ Follitropin Alfa Bioassay Kit

    cAMP Hunter Follitropin Alfa Bioassay Kits provide a functional, robust, highly sensitive, and easy-to-use cell-based assay to study potency and neutralizing antibodies for Follitropin Alfa and its analogues. The bioassay kits contain all the reagents needed for a complete assay including cells, detection reagents, cell plating reagent, positive control agonist...

    [User Manual] cAMP Hunter™ Follitropin Alfa Bioassay Kit