U2OS OXGR1 Gq Cell Line

Background Information:

The OXGR1 Gq cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. α-ketoglutarate) based activation of OXGR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses OXGR1 , a naturally Gq coupled GPCR. Upon activation of OXGR1 , the resulting calcium activity can be fluorescently assayed using the Calcium NoWash PLUS Detection Kit.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Oxoglutarate

Sub Family:

Class A

Coupling:

Gq

Protein Name:

OXGR1 (GPR99)

Protein Aliases:

2-oxoglutarate receptor 1|alpha-ketoglutarate receptor 1

Accession Number:

NM_080818.3

UniProt Number:

Q96P68

Gene Name:

OXGR1

Gene ID:

27199

Gene Aliases:

P2RY15|P2Y15|aKGR

Target Species:

Human

Cell Background:

U2OS