Biological Information

Background Information:

SPRINTer™ Endogenous Protein Turnover Biosensor Cell Lines are stable clonal cell lines used for monitoring drug-induced protein turnover of a specific endogenous target. Genome engineering or editing techniques, such as CRISPR/Cas9, are used to introduce a small tag into the endogenous locus of interest. This allows for the quantitation of changes in target protein levels when cells are treated with therapeutic agents such as targeted protein degraders.

Target Class:

Nuclear Protein

Family:

Transcription factor

Sub Family:

Basic Leucine Zipper Domain

Protein Name:

MYC

Accession Number:

NM_002467.6

UniProt Number:

P01106

Gene Name:

MYC

Gene ID:

4609

Gene Aliases:

c-Myc|bHLHe39|MYCC

Target Species:

Human

Cell Background:

K562

Usage

Product Type:

Stable Cell Lines

Application:

Targeted Protein Degradation

Storage Conditions:

Short term (24 h): Store in vapor phase of liquid nitrogen.

Usage disclaimer:

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Assay Information

Assay Type:

Cell Based

Assay Measures:

Targeted Protein Degradation (TPD)

Detection Method:

Chemiluminescence

Additional Information

Brand:

SPRINTer™