PathHunter® U2OS TORC2 Nuclear Translocation Cell Line

Background Information:

The PathHunter® U2OS TORC2 Nuclear Translocation Cell Line is a stable, engineered cell line for use in studying drug candidates affecting the CRTC/CREB pathway. This cell line enables assessment of ligand (e.g. forskolin) based pathway activation via detection of resulting TORC2 (CRTC2) nuclear translocation. This product uses EFC technology. The included cell line overexpresses PL-tagged TORC2 (CRTC2) and nuclear localized EA. Upon pathway activation, induced nuclear translocation of TORC2 leads to production of EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Nuclear Protein

Family:

Transcription factor

Protein Name:

TORC2

Protein Aliases:

TORC-2|Transducer of CREB protein 2

Accession Number:

NM_181715

UniProt Number:

Q53ET0

Gene Name:

CRTC2

Gene ID:

200186

Gene Aliases:

TORC2

Target Species:

Human

Cell Background:

U2OS