PathHunter® U2OS TORC1 Nuclear Translocation Cell Line

Background Information:

The PathHunter® U2OS TORC1 Nuclear Translocation Cell Line is a stable, engineered cell line for use in studying drug candidates affecting the CRTC/CREB pathway. This cell line enables assessment of ligand (e.g. forskolin) based pathway activation via detection of resulting TORC1 (CRTC1) nuclear translocation. This product uses EFC technology. The included cell line overexpresses PL-tagged TORC1 (CRTC1) and nuclear localized EA. Upon pathway activation, induced nuclear translocation of TORC1 leads to production of EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Nuclear Protein

Family:

Transcription factor

Protein Name:

TORC1

Protein Aliases:

Transducer of regulated cAMP response element-binding protein 1|TORC-1|Transducer of CREB protein 1

Accession Number:

NM_015321.1

UniProt Number:

Q6UUV9

Gene Name:

CRTC1

Gene ID:

23373

Gene Aliases:

KIAA0616|MECT1|TORC1|WAMTP1

Target Species:

Human

Cell Background:

U2OS