PathHunter® U2OS TIM3/TIM3 Dimerization Cell Line

Background Information:

The PathHunter® TIM3/TIM3 Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand induced dimerization of TIM3/TIM3 receptors. This product uses EFC technology. The cell line included overexpresses TIM3 target protein fused to PK alongside TIM3 target protein fused to EA. Upon ligand-induced dimerization of TIM3/TIM3 , detectable EFC signal is produced.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Checkpoint Receptor

Family:

T Cell Receptor

Protein Name:

TIM3

Protein Aliases:

T-cell immunoglobulin and mucin domain-containing protein 3|TIMD-3|T-cell immunoglobulin mucin receptor 3|TIM-3|T-cell membrane protein 3|CD antigen CD366

Accession Number:

NM_032782.4

UniProt Number:

Q8TDQ0

Gene Name:

HAVCR2

Gene ID:

84868

Gene Aliases:

TIM3|TIMD3

Target Species:

Human

Cell Background:

U2OS