PathHunter® U2OS TGFBR1/ACVR2B Dimerization Cell Line

Background Information:

The PathHunter® TGFBR1/ACVR2B Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. GDF-11) induced dimerization of TGFBR1/ACVR2B receptors. This product uses EFC technology. The cell line included overexpresses ACVR2B target protein fused to PK alongside TGFBR1 target protein fused to EA. Upon ligand-induced dimerization of TGFBR1/ACVR2B , detectable EFC signal is produced.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Kinase

Family:

TKL

Sub Family:

Protein Ser/Thr

Protein Name:

TGFBR1

Protein Aliases:

activin A receptor type II-like kinase, 53kDa

Accession Number:

NM_004612

UniProt Number:

P36897

Gene Name:

TGFBR1

Gene ID:

7046

Gene Aliases:

ALK-5|ACVRLK4|ALK5|SKR4

Target Species:

Human

Cell Background:

U2OS