PathHunter® U2OS SREBP2 Nuclear Translocation Cell Line

Background Information:

The PathHunter® U2OS SREBP2 Nuclear Translocation Cell Line is a stable, engineered cell line for use in studying drug candidates affecting the cholesterol biosynthesis pathway. This cell line enables assessment of ligand (e.g. 5'-UMP) based pathway activation via detection of resulting SREBP2 nuclear translocation. This product uses EFC technology. The included cell line overexpresses PL-tagged SREBP2 and nuclear localized EA. Upon pathway activation, induced nuclear translocation of SREBP2 leads to production of EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Nuclear Protein

Family:

Transcription factor

Protein Name:

SREBF2

Protein Aliases:

Class D basic helix-loop-helix protein 2|bHLHd2|Sterol regulatory element-binding transcription factor 2 [Cleaved into: Processed sterol regulatory element-binding protein 2]

Accession Number:

NM_004599.2

UniProt Number:

Q12772

Gene Name:

SREBF2

Gene ID:

6721

Gene Aliases:

BHLHD2|SREBP2

Target Species:

Human

Cell Background:

U2OS