PathHunter® U2OS PD-1/PD-1 Dimerization Cell Line

Background Information:

The PathHunter® PD-1/PD-1 Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. anti PD-1 antibody) induced dimerization of PD-1/PD-1 receptors. This product uses EFC technology. The cell line included overexpresses PD-1 target protein fused to PK alongside PD-1 target protein fused to EA. Upon ligand-induced dimerization of PD-1/PD-1 , detectable EFC signal is produced.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Checkpoint Receptor

Family:

T Cell Receptor

Protein Name:

PD-1

Protein Aliases:

hPD-1|CD antigen CD279

Accession Number:

NM_005018.2

UniProt Number:

Q15116

Gene Name:

PDCD1

Gene ID:

5133

Gene Aliases:

PD1

Target Species:

Human

Cell Background:

U2OS