Biological Information

Background Information:

The PathHunter® IL5RA/CSF2RB Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. IL-5) induced dimerization of IL5RA/CSF2RB receptors. This product uses EFC technology. The cell line included overexpresses CSF2RB target protein fused to PK alongside IL5RA target protein fused to EA. Upon ligand-induced dimerization of IL5RA/CSF2RB , detectable EFC signal is produced.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Cytokine Receptor

Family:

IL-3 Receptor

Protein Name:

IL5RA

Protein Aliases:

IL-5R subunit alpha|IL-5R-alpha|IL-5RA|CDw125|CD antigen CD125

Accession Number:

NM_000564.4

UniProt Number:

Q01344

Gene Name:

IL5RA

Gene ID:

3568

Gene Aliases:

IL5R

Target Species:

Human

Cell Background:

U2OS

Usage

Product Type:

Stable Cell Lines

Application:

Drug Discovery & Development

Storage Conditions:

Store in vapor phase of liquid nitrogen.

Usage disclaimer:

These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information

Assay Type:

Cell Based

Assay Measures:

Dimerization

Detection Method:

Chemiluminescence

Clinical Relevance

Therapeutic Area:

Inflammation/Allergy

Additional Information

Brand:

PathHunter®