PathHunter® U2OS FOXO3 Nuclear Translocation Cell Line

Background Information:

The PathHunter® U2OS FOXO3 Nuclear Translocation Cell Line is a stable, engineered cell line for use in studying drug candidates affecting the PI3 pathway. This cell line enables assessment of ligand (e.g. wortmannin) based pathway activation via detection of resulting FOXO3 nuclear translocation. This product uses EFC technology. The included cell line overexpresses PL-tagged FOXO3 and nuclear localized EA. Upon pathway activation, induced nuclear translocation of FOXO3 leads to production of EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Nuclear Protein

Family:

Transcription factor

Protein Name:

FOXO3

Protein Aliases:

Forkhead in rhabdomyosarcoma-like 1

Accession Number:

NM_201559.2

UniProt Number:

O43524

Gene Name:

FOXO3

Gene ID:

2309

Gene Aliases:

AF6q21|FOXO2

Target Species:

Human

Cell Background:

U2OS